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Visualising the architecture of G-protein coupled receptor interactions

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The architecture of the key regulatory protein beta-arrestin in complex with a G-protein coupled receptor (GPCR) has been elucidated by a combination of electron microscopy and mass spectrometry in a paper published in the journal Nature. The study comes from a research team from Duke Medicine, the University of Michigan and Stanford University. The study should help advance understanding of how cells transmit signals and how signalling is controlled in the body's response to stimuli including light and pain.

GPCRs are seven transmembrane spanning structures which operate in a multitude of cell signalling pathways. As a group, they represent the largest drug target family for human diseases as disparate as cardiovascular disease, neurological disease and cancer. Co –senior author on the paper, Dr Robert J. Lefkowitz of Duke University School of Medicine and the Howard Hughes Medical Institute, explains the importance of insights into the structure of GPCRs: "It is crucial to visualize how these receptors work to fully appreciate how our bodies respond to a wide array of stimuli, including light, hormones and various chemicals." Dr Lefkowitz shared the Nobel Prize for Chemistry in 2012 with one of the other senior co-authors on the paper, Dr Brian K. Kobilka, of Stanford University School of Medicine, for their work on GPCRs.

In this paper, the authors presented a visualisation of the protein beta-arrestin in complex with the ‘fight-or-flight’ associated beta 2-adrenergic receptor. Beta-arrestins function to desensitise and therefore cap GPCR signalling and to initiate a new wave of GPCR-independent signalling. Another co-senior author, Dr Georgios Skiniotis of the University of Michigan further explains: "Arrestin's primary role is to put the cap on GPCR signaling. Elucidating the structure of this complex is crucial for understanding how the receptors are desensitized in order to prevent aberrant signalling." The research team formed and purified a functional human β2AR–β-arrestin-1 complex. Using mass spectrometry, cross-linking analysis and electron microscopy, they were able to confirm a previously suspected but not demonstrated bimodal binding, involving two separate interactions between beta-arrestin and both the intracellular carboxy tail of the GPCR and with its 7 transmembrane core.

The authors now plan to bring X-ray crystallography into play in order to attain atomic level insights into this architecture. These details could then be harnessed in experiments aimed at novel drug design and for gaining improved understanding of the fundamentals of GPCR biology. Co-lead author Arun K. Shukla concludes: “This is just a start and there is a long way to go…We have to visualize similar complexes of other GPCRs to develop a comprehensive understanding of this family of receptors."

Sources

Shukla, A.K. et al (2014). Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature (June 22 2014); doi:10.1038/nature13430

Press release: Duke University Medical Center; available from http://www.eurekalert.org/pub_releases/2...061914.php

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JBEI GT collection is a new biofuels research resource

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Efforts to advance production of environmentally friendly transportation fuels from plant biomass should be aided by a new glycosyltransferase clone collection compiled by researchers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI). A paper on the collection has been accepted for publication in The Plant Journal. The aim of the JBEI GT collection is to provide a functional genomic for researchers in the field of sugar extraction from plant biomass to product fuels.

Glycosyltransferases (GT) are the enzymes responsible for catalysis of simple plant monosaccharides into complex polysaccharides needed for many plant cells function and structures. Large GT families have evolved in plants but their chemical nature has hampered efforts to understand specific functions of the majority of GTs. This hinders bioenergy research efforts to modify plant biomass with a goal to produce maximum amounts of transportation fuels.

In an attempt to address this issue, the JBEI team, led by Dr Joshua Heazlewood, director of the JBEI Plant Systems Biology Programme, have cloned and verified the new clone collection which contains 403 Arabidopsis GTs (the reference plant for poplar and other similar species) and 96 rice GTs (the reference plant for grasses). This represents about 88% of the known Arabidopsis GTs but only about 15% of rice GTs, so the team aim to extend this. Dr Heazlewood explains the ethos and utility behind the clone collection: “Using the unique infrastructure and resources at JBEI, we have provided a collection of high quality GT clones, all of which have been verified by sequencing and are available in easy to use cassettes…We’re making this entire collection available to the plant research community and expect it to drive our basic understanding of GTs and enable the manipulation of cell walls.”

As well as the GT clone collection, the team have produced a set of so-called ‘pBullets’ which are particle bombardment plasmids that mark targeted protein location with high efficiency when shot into cells. The JBEI pBullets are designed to mark elements of the plant endomembrane system, which separates the functional and structural plant cell components. Dr Heazlewood explains how this system could be useful: “Our pBullet vector series is custom designed for efficient bombardment…Researchers generally use large unwieldy plasmids that perform badly when it comes to localizing proteins.”
More information on the JBEI GT collection and the pBullets can be found on the JBEI Website at http://gt.jbei.org/

Sources

Lao, J. et al. (2014). The Plant Glycosyltransferase Clone Collection for Functional Genomics. The Plant Journal (accepted article); DOI: 10.1111/tpj.12577

Press release: The Berkeley Lab; available from https://newscenter.lbl.gov/2014/06/23/th...ollection/ [Accessed 24 June 2014].

International Association of Plant Biotechnology Congress | August 10-15 | Melbourne

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International Association of Plant Biotechnology Congress 2014

Organisers: International Association for Plant Biotechnology

Dates: August 10th-15th, 2014

Location: Melbourne Convention and Exhibition Centre, Melbourne, Australia

Website: http://www.iapb2014congress.com/

The website gives all the necessary information on conference agenda, hotel, exhibitions and other important facts.

The congress features a comprehensive programme covering multiple aspects of plant biotechnology with an international line-up of plenary and keynote speakers.

Symposia topics:
• Abiotic stress
• Bioenergy
• Bioinformatics
• Biopharma, bioproducts and bioprospecting
• Biosafety and acceptance
• Biotic stress
• Cereals
• Communicating innovation
• Crop biofortification & nutritional enhancement
• Economics and social benefits
• Emerging technologies
• Forages
• Forestry
• Gene expression
• Gene stacking
• Genomics
• Grain legumes
• Horticulture and ornamentals
• Innovations in in vitro culture/propagation
• Metabolomics & proteomics
• Microbiomes & plant-microbe interactions
• Molecular breeding
• Next-generation breeding technologies & innovations in gene transfer to plants
• Nutrient uptake & phytoremediation
• Oil and fibre crops
• Phenomics
• Regulation of new breeding technologies
• Tuber and root crops
• Yield

Plenary and Keynote Speakers
• Tom Adams, USA
• Julian Adams, USA
• Arie Altman, Israel
• Marilyn Anderson, Australia
• Jim Birchler, USA
• Stevens Brumbley, USA
• Jorge Canhoto, Portugal
• Henry Daniell, USA
• Swapan Datta, India
• Barbara De Coninck, Belgium
• Sacco de Vries, Netherlands
• Sharon Doty, USA
• Nina Fedoroff, Saudi Arabia
• Brett Ferguson, Australia
• Geoff Fincher, Australia
• Rainer Fischer, Germany
• Richard Flavell, USA
• Robert Furbank, Australia
• Stanton Gelvin, USA
• Yuri Gleba, Germany
• Jonathan Gressel, Israel
• Wilhelm Gruissem, Zurich
• Robert Hall, Netherlands
• Robert Henry, Australia
• Bertrand Hirel, France
• Jeanne Jacobs, New Zealand
• Beat Keller, Switzerland
• Jens Kossmann, South Africa
• Juergen Logemann, Germany
• Cathie Martin, United Kingdom
• Ying Miao, China
• Maurice Moloney, Australia
• Hilde Nelissen, Belgium
• David Ow, China
• James Petrie, Australia
• Ingo Potrykus, Switzerland
• Elibio Rech, Brazil
• Philippe Rigault, Canada
• Patrick Schnable, USA
• Lakshmi Sastry-Dent, USA
• Patrick Schnable, USA
• Kazuo Shinozaki, Japan
• Alex Sorokin, Singapore
• Erin Sparks, USA
• Satoshi Tabata, Japan
• Acram Taji, Australia
• Marc Van Montagu, Belgium
• Rajeev Varshney, India
• Ry Wagner, USA
• Zeng-Yu Wang, USA
• Jim Whelan, Australia
• William Wilson, USA
• Zhongchao Yin, Singapore
• Ulrich Zimmermann, Germany

How to test if Antibodies binded biotin or not

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Hello everyone,

My name is Masino and I am studying Bio- and Nanotechnology in Iserlohn, Germany. I am starting to work on my bachelor thesis in which I have to bind biotin on interleukin 1 antibodies. After that I need a method to check which antibodies binded the biotin and which not. Does someone of you have an idea? Thanks !

Common genes associated with schizophrenia and cannabis use

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An individual’s profile of schizophrenia risk genes is associated with an increased risk of cannabis use. This is the main finding in a paper from an international team of researchers published today as an advanced online publication in the journal Molecular Psychiatry. The findings do not rule out a causal relationship between cannabis use and risk of developing schizophrenia but do suggest that the relationship may also work the other way, i.e. that genetic predisposition to schizophrenia may also increase the likelihood of using cannabis.

Cannabis is the most commonly used illegal drug internationally. In some countries, there is intense debate on the issue of legalising and controlling cannabis use, so increased insight into the health risks associated with cannabis are more pressing than ever. Schizophrenia is a devastating psychiatric disorder which affects about 1% of the population and commonly features auditory hallucinations and delusions. There is substantial evidence to suggest that cannabis is one causal component for schizophrenia, however there is debate around whether this is completely due to cannabis increasing psychosis risk or whether the genes that contribute to increased risk of psychosis also contribute to increased risk of cannabis use.

In an attempt to address this debate, the research team recruited 2082 healthy individuals of whom 1011 had used cannabis. They established the ‘schizophrenia genetic risk profile’ for each person, i.e. the number of genetic variants considered to be predisposing to schizophrenia. The results indicated that individuals who had a genetic predisposition to cancer were more likely to use cannabis and in greater quantities than those who did not have the schizophrenia genetic risk factors.

First author Robert Power, of King's College London, explains the significance of the results: "We know that cannabis increases the risk of schizophrenia. Our study certainly does not rule this out, but it suggests that there is likely to be an association in the other direction as well – that a pre-disposition to schizophrenia also increases your likelihood of cannabis use." Mr Power concludes: "Our study highlights the complex interactions between genes and environments when we talk about cannabis as a risk factor for schizophrenia. Certain environmental risks, such as cannabis use, may be more likely given an individual's innate behaviour and personality, itself influenced by their genetic make-up. This is an important finding to consider when calculating the economic and health impact of cannabis."

So the debate continues on the complex links between cannabis use and schizophrenia risk and should be an important consideration in discussions of cannabis legalisation.

Sources:
Power, R.A. et al. (2014). Genetic predisposition to schizophrenia associated with increased use of cannabis. Molecular Psychiatry advance online publication 24 June 2014; doi: 10.1038/mp.2014.51

Press release: King’s College London; available from http://www.eurekalert.org/pub_releases/2...062314.php [Accessed 24 June 2014]

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Need help for a Drosophila PCR!! Help!!!

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Hello to all! I'm a PhD student and I'm working on Drosophila S2 cells. My task is to make a PCR to show the presence or not of a rat transfected gene. All is ok with the PCR with other cell types, but when I run it on S2 cells I obtain no results, even with housekeeping gene primers. I'd to know if anyone of you have had any problems with these cells and how you solved them. Thank you in advance to anyone will help me!!! Smile

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A new biotech product from China---EHFPI

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EHFPI, a database of Essential Host Factors (EHFs) for Pathogenic Infections. EHFs are a group of host cellular genes identified from (genome-wide) RNA interference (RNAi) screens, the knockdown effect of which greatly influences the infection of a pathogen but not the viability of host cells (designated as "confirmed hits", see the workflow chart below for detailed information). less http://lnkd.in/bgekf4f

SALES POSITION at BIOTECH MNC base in Singapore

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WHERE WILL YOU BE 3-10 YEARS LATER?
Typical career path of a technical related position (such as biologist/ chemist/ engineer):
Fresh entry (salary $2000 +/-) >
Junior position (salary: $2700 +/-) >
Senior position (salary: $3900 +/-) >
Manager level: Regional Senior Chemist/ Principle Chemist (salary: $5000 to $6000)
That is probably the high level you may achieve in your career path

WHY SALES?
Commission itself could be $5000 - $6000 already.
Typical career path of a sales related position:
Fresh entry (basic $2000 + commission with no cap) >
Junior position such as Sales Executive (basic $2400 + commission with no cap) >
Senior position such as Senior Sales Executive (basic $3000 + commission with no cap) >
Manager level such as Sales Manager (Basic $4800 + over riding with no cap) >
Senior manager level such as Senior Sales Manager ($7700 + High performance bonus + benefit) >
Top level such as Sales/ Business Development Director, Regional Director, etc… salary can be easily above $10,000 to above $20,000 per month.

WHO HIRING?
A Biotechnology MNC based in Singapore is currently expanding their sales team. Candidates shall expect tough challenges and fast moving pace working under a MNC.

JOB DESCRIPTIONS
Work as a Sales Consultant for a recognized Multinational Corporation is the best way to learn and build your career path.

Your job scope includes but not limited to:
> Respond to customers provided by company.
> Attending road show to promote company services.
> Meeting customers to conduct professional presentation.
> Build and maintain relationship with doctors, practitioner and nurses.
> Responsible for delivering assigned sales targets and report to Sales Manager.
> Actively research and develop strategies to seek new business opportunity.
> Follow up and evaluate with customers on product success and feedback.
> Build and sustain relationships with decision makers.
> Establishment strong relationship with current customers.

REQUIREMENTS
> Degree in Biotechnology, life sciences, chemistry or its equivalent
> Candidate with no experience, training will be provided
> Candidate with diploma should have at least 2 to 3 years of sales experiences
> Candidates with more sales experiences may be allocated for senior position
> MUST have passion
> Possess strong presentation, organization, administrative and communication skills
> Good computer skill, proficiency in MS office PowerPoint
> Fluent in written and spoken English

For further information, kindly email your resume to: keni@collars.com.sg

Regards,
Keni Ng
Managing Consultant,
Biotechnology and Chemical Industry

269C New Bridge Road
Singapore 088747

Registration Number: R1436445
Employment Agency License Number: 14C7013

SAP EHS (Environment , Health & Safty ) Online Training

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SAP EHS (Environment , Health & Safty ) Online Training

SAP EHS Online training – Live Instructor Led Training From Certified Trainer– Elite Tech Solutions Pvt ltd SAP EHS Online Training Details :
Course Duration : 35 Hours
Course Type : Online Training
Course Material will be provided
Certified Trainers
Pre requisition : There no pre requisition Any Graduate or post graduate can learn this course engineers, safety professionals, other sap module professionals (like ps, mm, sd etc), pharmacy professionals, etc who are learning and getting placed
SAP EHS supports the management of industrial hygiene, safety, and occupational health processes. SAP EHS Management helps you ensure compliance with regulations for product safety, hazardous substances, dangerous goods, and waste management.
SAP EH&S – Product Safety : Product Safety sub module in SAP EHS allow companies to manage chemicals, substances, materials, etc using the Specification Information System. Since global companies ship their materials to many countries, the information about products and materials is built using phrases in SAP. Phrase Management allows managing information in phrases there by making it easy to translate the information in multiple languages as each phrase is stored in several languages relevant to the customer. Material Safety Data Sheet (MSDS) is the most commonly generated and distributed report by manufacturing companies. Product Safety module enables efficient management of these reports and shipment of these reports using report shipping tools.
SAP EH&S – Dangerous Goods Management: With Dangerous Goods Management module, you can manage dangerous goods relevant data in SAP and define checks that need to be performed while selling, shipping and handling dangerous goods.
SAP EH&S – Industrial Hygiene & Safety : Industrial Hygiene and Safety sub module enables you to define work areas in your company, record exposures and assess risks associated with certain exposures and work areas.
SAP EH&S – Occupational Health : With this component, you can manage occupational health protocols established within your organization.
SAP EH&S – Waste Management : Waste Management enables you to handle and dispose industrial waste while complying to the federal, state and international waste standards. SAP EHS TRAINING contents General Overview of EH&S Basic data and tools Creation of Phrase Creation of Phrase sets Creation of Phrase Library Creation of Phrase Groups Phrase set assignments Master data match up Value Assignment Types Product Safety /Hazardous Substance Specification Management Phrase Management EH&S Expert Report Generation & Report Management Material Safety Data Sheet Shipping EH&S Web Interface (Portal) Global Label Management Substance Volume Tracking(SVT) Life-Cycle Assessment Ariel Staging and CED quarterly Updates Customs Classification: Compliance Questionnaire Workflow for Product Safety Industrial Hygiene & Safety Standard WWI Incident/Accident -OSHA (Occupational Safety and Health Administration ) Reports Customized EHS WWI(Win Word Integrator) Explain how to create general report template with WWI IHS Information System Safety Measures Site Inspection Waste Management Waste Basic Data Management Waste Disposal/Waste Inventory Management Dangerous Goods Management Introduction to DG Regulations and classifications Dangerous Goods Master data management Dangerous goods master filling and structure DG Checks and DG documents

Contact Name:Varun, or venky , skype name elitetechsap Elite Tech Solutions Pvt Ltd http://elitetech-solutions.in Ph no: 91-8019245457, 91-8712118291, 91-9704628488, 91-8050839701,
E-mail: varunsap08@gmail.com, hr@elitetech-solutions.in jhvenky@gmail.com (please response through email only for fast response) Bangalore

SAP EHS (Environment , Health & Safty ) Online Training

0
0
SAP EHS (Environment , Health & Safty ) Online Training


SAP EHS Online training – Live Instructor Led Training From Certified Trainer– Elite Tech Solutions Pvt ltd SAP EHS Online Training Details :
Course Duration : 35 Hours
Course Type : Online Training
Course Material will be provided
Certified Trainers
Pre requisition : There no pre requisition Any Graduate or post graduate can learn this course engineers, safety professionals, other sap module professionals (like ps, mm, sd etc), pharmacy professionals, etc who are learning and getting placed
SAP EHS supports the management of industrial hygiene, safety, and occupational health processes. SAP EHS Management helps you ensure compliance with regulations for product safety, hazardous substances, dangerous goods, and waste management.
SAP EH&S – Product Safety : Product Safety sub module in SAP EHS allow companies to manage chemicals, substances, materials, etc using the Specification Information System. Since global companies ship their materials to many countries, the information about products and materials is built using phrases in SAP. Phrase Management allows managing information in phrases there by making it easy to translate the information in multiple languages as each phrase is stored in several languages relevant to the customer. Material Safety Data Sheet (MSDS) is the most commonly generated and distributed report by manufacturing companies. Product Safety module enables efficient management of these reports and shipment of these reports using report shipping tools.
SAP EH&S – Dangerous Goods Management: With Dangerous Goods Management module, you can manage dangerous goods relevant data in SAP and define checks that need to be performed while selling, shipping and handling dangerous goods.
SAP EH&S – Industrial Hygiene & Safety : Industrial Hygiene and Safety sub module enables you to define work areas in your company, record exposures and assess risks associated with certain exposures and work areas.
SAP EH&S – Occupational Health : With this component, you can manage occupational health protocols established within your organization.
SAP EH&S – Waste Management : Waste Management enables you to handle and dispose industrial waste while complying to the federal, state and international waste standards. SAP EHS TRAINING contents General Overview of EH&S Basic data and tools Creation of Phrase Creation of Phrase sets Creation of Phrase Library Creation of Phrase Groups Phrase set assignments Master data match up Value Assignment Types Product Safety /Hazardous Substance Specification Management Phrase Management EH&S Expert Report Generation & Report Management Material Safety Data Sheet Shipping EH&S Web Interface (Portal) Global Label Management Substance Volume Tracking(SVT) Life-Cycle Assessment Ariel Staging and CED quarterly Updates Customs Classification: Compliance Questionnaire Workflow for Product Safety Industrial Hygiene & Safety Standard WWI Incident/Accident -OSHA (Occupational Safety and Health Administration ) Reports Customized EHS WWI(Win Word Integrator) Explain how to create general report template with WWI IHS Information System Safety Measures Site Inspection Waste Management Waste Basic Data Management Waste Disposal/Waste Inventory Management Dangerous Goods Management Introduction to DG Regulations and classifications Dangerous Goods Master data management Dangerous goods master filling and structure DG Checks and DG documents

Contact Name:Varun, or venky , skype name elitetechsap Elite Tech Solutions Pvt Ltd http://elitetech-solutions.in Ph no: 91-8019245457, 91-8712118291, 91-9704628488, 91-8050839701,
E-mail: varunsap08@gmail.com, hr@elitetech-solutions.in jhvenky@gmail.com (please response through email only for fast response) Bangalore

SAP EHS (Environment , Health & Safty ) Online Training

0
0
SAP EHS (Environment , Health & Safty ) Online Training


SAP EHS Online training – Live Instructor Led Training From Certified Trainer– Elite Tech Solutions Pvt ltd SAP EHS Online Training Details :
Course Duration : 35 Hours
Course Type : Online Training
Course Material will be provided
Certified Trainers
Pre requisition : There no pre requisition Any Graduate or post graduate can learn this course engineers, safety professionals, other sap module professionals (like ps, mm, sd etc), pharmacy professionals, etc who are learning and getting placed
SAP EHS supports the management of industrial hygiene, safety, and occupational health processes. SAP EHS Management helps you ensure compliance with regulations for product safety, hazardous substances, dangerous goods, and waste management.
SAP EH&S – Product Safety : Product Safety sub module in SAP EHS allow companies to manage chemicals, substances, materials, etc using the Specification Information System. Since global companies ship their materials to many countries, the information about products and materials is built using phrases in SAP. Phrase Management allows managing information in phrases there by making it easy to translate the information in multiple languages as each phrase is stored in several languages relevant to the customer. Material Safety Data Sheet (MSDS) is the most commonly generated and distributed report by manufacturing companies. Product Safety module enables efficient management of these reports and shipment of these reports using report shipping tools.
SAP EH&S – Dangerous Goods Management: With Dangerous Goods Management module, you can manage dangerous goods relevant data in SAP and define checks that need to be performed while selling, shipping and handling dangerous goods.
SAP EH&S – Industrial Hygiene & Safety : Industrial Hygiene and Safety sub module enables you to define work areas in your company, record exposures and assess risks associated with certain exposures and work areas.
SAP EH&S – Occupational Health : With this component, you can manage occupational health protocols established within your organization.
SAP EH&S – Waste Management : Waste Management enables you to handle and dispose industrial waste while complying to the federal, state and international waste standards. SAP EHS TRAINING contents General Overview of EH&S Basic data and tools Creation of Phrase Creation of Phrase sets Creation of Phrase Library Creation of Phrase Groups Phrase set assignments Master data match up Value Assignment Types Product Safety /Hazardous Substance Specification Management Phrase Management EH&S Expert Report Generation & Report Management Material Safety Data Sheet Shipping EH&S Web Interface (Portal) Global Label Management Substance Volume Tracking(SVT) Life-Cycle Assessment Ariel Staging and CED quarterly Updates Customs Classification: Compliance Questionnaire Workflow for Product Safety Industrial Hygiene & Safety Standard WWI Incident/Accident -OSHA (Occupational Safety and Health Administration ) Reports Customized EHS WWI(Win Word Integrator) Explain how to create general report template with WWI IHS Information System Safety Measures Site Inspection Waste Management Waste Basic Data Management Waste Disposal/Waste Inventory Management Dangerous Goods Management Introduction to DG Regulations and classifications Dangerous Goods Master data management Dangerous goods master filling and structure DG Checks and DG documents

Contact Name:Varun, or venky , skype name elitetechsap Elite Tech Solutions Pvt Ltd http://elitetech-solutions.in Ph no: 91-8019245457, 91-8712118291, 91-9704628488, 91-8050839701,
E-mail: varunsap08@gmail.com, hr@elitetech-solutions.in jhvenky@gmail.com (please response through email only for fast response) Bangalore

SAP EHS (Environment , Health & Safty ) Online Training @ Elite Tech

0
0
SAP EHS (Environment , Health & Safty ) Online Training


SAP EHS Online training – Live Instructor Led Training From Certified Trainer– Elite Tech Solutions Pvt ltd SAP EHS Online Training Details :
Course Duration : 35 Hours
Course Type : Online Training
Course Material will be provided
Certified Trainers
Pre requisition : There no pre requisition Any Graduate or post graduate can learn this course engineers, safety professionals, other sap module professionals (like ps, mm, sd etc), pharmacy professionals, etc who are learning and getting placed
SAP EHS supports the management of industrial hygiene, safety, and occupational health processes. SAP EHS Management helps you ensure compliance with regulations for product safety, hazardous substances, dangerous goods, and waste management.
SAP EH&S – Product Safety : Product Safety sub module in SAP EHS allow companies to manage chemicals, substances, materials, etc using the Specification Information System. Since global companies ship their materials to many countries, the information about products and materials is built using phrases in SAP. Phrase Management allows managing information in phrases there by making it easy to translate the information in multiple languages as each phrase is stored in several languages relevant to the customer. Material Safety Data Sheet (MSDS) is the most commonly generated and distributed report by manufacturing companies. Product Safety module enables efficient management of these reports and shipment of these reports using report shipping tools.
SAP EH&S – Dangerous Goods Management: With Dangerous Goods Management module, you can manage dangerous goods relevant data in SAP and define checks that need to be performed while selling, shipping and handling dangerous goods.
SAP EH&S – Industrial Hygiene & Safety : Industrial Hygiene and Safety sub module enables you to define work areas in your company, record exposures and assess risks associated with certain exposures and work areas.
SAP EH&S – Occupational Health : With this component, you can manage occupational health protocols established within your organization.
SAP EH&S – Waste Management : Waste Management enables you to handle and dispose industrial waste while complying to the federal, state and international waste standards. SAP EHS TRAINING contents General Overview of EH&S Basic data and tools Creation of Phrase Creation of Phrase sets Creation of Phrase Library Creation of Phrase Groups Phrase set assignments Master data match up Value Assignment Types Product Safety /Hazardous Substance Specification Management Phrase Management EH&S Expert Report Generation & Report Management Material Safety Data Sheet Shipping EH&S Web Interface (Portal) Global Label Management Substance Volume Tracking(SVT) Life-Cycle Assessment Ariel Staging and CED quarterly Updates Customs Classification: Compliance Questionnaire Workflow for Product Safety Industrial Hygiene & Safety Standard WWI Incident/Accident -OSHA (Occupational Safety and Health Administration ) Reports Customized EHS WWI(Win Word Integrator) Explain how to create general report template with WWI IHS Information System Safety Measures Site Inspection Waste Management Waste Basic Data Management Waste Disposal/Waste Inventory Management Dangerous Goods Management Introduction to DG Regulations and classifications Dangerous Goods Master data management Dangerous goods master filling and structure DG Checks and DG documents

Contact Name:Varun, or venky , skype name elitetechsap Elite Tech Solutions Pvt Ltd http://elitetech-solutions.in Ph no: 91-8019245457, 91-8712118291, 91-9704628488, 91-8050839701,
E-mail: varunsap08@gmail.com, hr@elitetech-solutions.in jhvenky@gmail.com (please response through email only for fast response) Bangalore

Admission into NUS for Masters

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What are my chances of getting admission into NUS in Department of Chemical and Biomolecular Engg? Ive got first class with distinction in my B.tech with a GATE percentile of 93 and my GRE score is 313. I have done my final year project in Molecular Biology. Do I have to take TOEFL?

Sex distortion of mosquitoes in control of malaria spread

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A ‘sex-distorting’ approach to control malaria-spreading mosquitoes, first proposed in theory sixty years ago, my be closer to reality. A new study in the journal Nature Communications from an international team led by researchers in Imperial College London, describes use of an endonuclease from slime mould to selectively shred the X chromosome of the malaria mosquito vector Anopheles gambiae. This has a two-fold effect as it results in males having almost exclusively male offspring, leading to reductions in population over time and also reduces malaria spread as only female mosquitoes bite humans and transmit malaria.

Malaria remains a serious public health issue, most notably in sub-Saharan Africa. The disease kills hundreds of thousands of people every year. In mosquitoes, like humans, normal sperm contains 50% X and 50% Y chromosomes. The current study exploited the fact that the endonuclease I-Ppol selectively targets cutting sites located exclusively on the X chromosome of Anopheles gambiae. The research team used a combination of protein engineering and molecular genetics to produce male mosquitoes in which the I-Ppol was turned on only during spermatogenesis. Therefore, these males produced almost no X chromosome-containing sperm as the X chromosomes were shredded by the endonuclease, and hence very few female offspring. Importantly, the modification was heritable so that many of the male offspring of the original males also produced few female offspring.

The results were striking. In five test cages originally containing 50 males and 50 females each, introduction of 150 sex-distorter males resulted in a major reduction in females over 4 generations and in complete loss of the population after another 2 generations in 4 out of 5 cages. The results are promising and are unlikely to have a serious impact on the surrounding ecosystem as, for example, it specifically targets the malarial mosquito unlike pesticides which are more indiscriminate. However, the system is some years away from deployment in the field.

Commentators have welcomed the study but point out that targeting the Y chromosome would represent a better long-term strategy as the modified males would pass the change on to all of their male offspring and there would be less dilution of the effect than would be likely with the system in the current study, which would probably need ‘topping up’ over time. The authors of the current paper agree with this analysis and in fact have been working on gene insertions in the mosquito Y chromosome. Thus the future looks promising for harnessing of sex-distorting strategies to control spread of malaria.

Sources

Galizi, R., Doyle, L. A., Menichelli, M., Bernardini, F., Deredec, A., Burt, A., Stoddard, B. L., Windbichler, N., and Crisanti, A. (2014). A synthetic sex ratio distortion system for the control of the human malaria mosquito. Nature Communications, Vol. 5 (10 June 2014), doi:10.1038/ncomms4977

BBC News; available from http://www.bbc.com/news/science-environment-27765974 [Accessed 13 June 2014]

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