SAS, Clinical Research, Clinical Data Management CDM, Oracle Clinical, Bioinformatics

June 27, 2012, 9:47 pm

≫ Next: Shenfu injection on hypoxic-ischemic brain damage in neonatal rat ATF4

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Trainings & Projects – Bioinformatics, Clinical Research, Pharma Research, CDM, Oracle Clinical OC/RDC and SAS

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Shenfu injection on hypoxic-ischemic brain damage in neonatal rat ATF4

June 29, 2012, 2:47 am

≫ Next: Question: Is Bioinformatics a Good Job for a Quadriplegic

≪ Previous: SAS, Clinical Research, Clinical Data Management CDM, Oracle Clinical, Bioinformatics

Hypoxic-ischemic brain damage (HIBD) occur in approximately 6 per 1,000 live births, 25% -30% of the survivors may leave some type of long-term sequelae. The study found that hypoxia, ischemia, low sugar, the ATP depletion, a large number of free radicals such as calcium overload can trigger endoplasmic reticulum stress (ERS), the start of the unfolded protein response (of UPR). Eukaryotic activate the transcription factor (ATF4) is the key factor of the PKR-like endoplasmic reticulum kinase (the PERK)-mediated UPR pathway. Shenfu injection main components of ginseng saponin and Aconitum alkaloids have a protective effect on brain injury.

But see note whether the injection from the cerebral protective effects by reducing the ERS, has yet to see the related reports.In the normal state, the PERK dimerization sites immunoglobulin binding protein (the Bip) cover, no endonuclease activity. ERS, a large number of Bip protein was used in conjunction with the unfolded protein PERK free, polymerization, phosphoric acid, so that the PERK itself to activate the substrate and catalyze eIF2 phosphorylation. Involved in mammalian cell protein translation initiation complex formation, eIF2 protein A, B, C, three kinds of subunits, A serine can be phosphorylated in. Phosphorylated eIF2 can inhibit the GDP-GTP exchange function, making the eIF2 can not be reused, reducing the start codon recognition rate, thus inhibiting protein synthesis in the boot process to reduce the level of translation. Although eIF2 phosphorylation lead to overall translational repression, but it can still specifically induced increase ATF4 mRNA translation. ATF4 expression, including the endoplasmic reticulum stress in cells is dependent on PERK-mediated eIF2 phosphorylation.ATF4 to regulate C / EBP homologous protein, growth arrest and DNA damage inducible protein 34 and activating transcription factor 3 (of ATF3) expression, which, of ATF3 also promote CHOP and GADD34 expression. CHOP and endoplasmic reticulum stress-induced apoptosis by down-regulating expression of Bcl-2 expression, increase Bim expression, depletion of glutathione, the promotion of ROS generation, activation of caspase-3, ultimately leading to cell apoptosis.Results found that the the HIBD ischemia in neonatal rat lateral prefrontal cortex of eIF2, ATF4 protein levels increase, showed that of eIF2, the ATF4 involved in the the HIBD pathological physiological processes. The HIBD likely to start the PERK-mediated UPR pathway.
http://www.creativebiomart.net/

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Question: Is Bioinformatics a Good Job for a Quadriplegic

June 30, 2012, 11:25 am

≫ Next: From the prokaryotic expression of macrophage-related genes ATG5

≪ Previous: Shenfu injection on hypoxic-ischemic brain damage in neonatal rat ATF4

Hello, I am a vocational rehabilitation counselor who is trying to help a quadriplegic choose an appropriate college major/career. His stated interest to me was to study DNA using the convergence of computers and biology. After a chunk of research on my part it appears the field he is interested in is Bioinformatics [though I've seen genetic engineer, gene sequencer and other job titles].

The young man is wheelchair dependent, but has functioning bicep muscles that let him use his arms and hands to type, but not very quickly [lower arms/hands are fully paralyzed]. I emailed a noted Bioinformatician and he said the field is divided into two job types: Bioinformaticians who require very heavy coding and Annotators who are basically just biologists who do light work part time. He said there's no in-between.

The worst thing that can happen is for him to take out enormous loans and spend years of his life working towards a goal that is unrealistic. If heavy coding is an essential job function, employers will likely not have to reasonably accommodate him under the Americans with Disability Act. It is imperative he choose a career path/major wisely now.

Any information you can provide on the job, or suggestions for a more appropriate alternate career in the field, would be immensely helpful.

Thanks.

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From the prokaryotic expression of macrophage-related genes ATG5

July 1, 2012, 7:39 pm

≫ Next: Manufacture of vascular smooth muscle cells from the patient's skin

≪ Previous: Question: Is Bioinformatics a Good Job for a Quadriplegic

Autophagy is an important degradation mechanism in the cell by autophagy, intracellular delivery of aging proteins to lysosomes for degradation. Early studies suggested that autophagy is mainly an adaptive response of the state of hunger. However, recent studies suggest that, in the course of neurodegenerative diseases, tumors, pathogen infection, autophagy play a significant role, even without the presence of any abnormal protein, loss of autophagy can lead to diseases. The expression of autophagy-related gene (ATG) has an important role in the maturation of autophagy regulation, the different stages of the formation of autophagosomes, different ATG molecular regulation. To be sure, ATG, genes play an important role in the process of autophagy, but must be clear ATG molecules involved in the formation of a series of molecular mechanisms of autophagy is still lack of identification and testing materials. ATG5 is the formation of an important gene for autophagy, in order to study the role of autophagy in disease, in vitro expression and purification of the reorganization of ATG5, and preparation of a polyclonal anti-ATG5 antibody, in order to study autophagy and development testing and research tools.Cell autophagy and cell phagocytosis is the intrusion of cellular defense in two different but related process, phagocytosis of extracellular antigens wrapped and endocytosis, autophagy can be wrapped in the cytoplasm of pathogens, proteins and organelles of the double-layer membrane structure, followed by phagosome or combined autophagosomes with lysosomes and decomposition of the contents. Autophagy plays an important role in cell growth, development and disease.

With the successful identification of key molecules involved in autophagic programmed cell death pathway, the molecular mechanism of autophagy, the physiological function and role in the pathological process in a better understanding. Relative to the major degradation of the short half-life of protein ubiquitin - proteasome system, cells, autophagy is involved in the vast majority of long half-life of protein degradation. On the morphology, the development of autophagic vacuoles wrapped with bilayer membrane degeneration and necrosis of the cell and part of the cytoplasm, autophagic vacuoles, since macrophages bubble's outer membrane with the lysosomal membrane fusion, the material of the endometrium and its packages into the lysosomal lumen, the lysosomal enzyme hydrolysis. The study found that ATG5 as the cells switch for autophagy and apoptosis, plays an important regulatory functions in the occurrence of autophagy and development. Autophagic vacuoles in the early stages, ATG12-ATG5-ATG16I the formation of complexes of its outer membrane combination, this combination on the one hand promote stretching expansion of autophagic vacuoles, so that by the beginning of the small vesicles half ring structure; ATG5 complex and autophagic vacuoles membrane binding also promotes microtubule associated protein light chain 3 (LC3.) to the autophagic vacuoles move and concentrate. ATG5 complex in the membrane position determines the bending direction of the membrane, the membrane extending toward the direction of the ATG5 complex. When located in the bilayer membrane structure of autophagic vacuoles form a closed circular shape, or just closed ATG5 complex will be from the down by double-layer membrane, leaving only the membrane-bound form of LC3.-II autophagy taking a dip. Studies have shown that macrophages lack ATG5 lysosomes can not be fusion with the phagosome. In addition, Yousefi, a ATG5 was calcium-dependent neutral protease the caplain specific cutting the proteins transferred from the cytoplasm to the mitochondria, and anti-apoptotic molecule Bcl-X regulation of cytochrome C release and caspase activation and thus significantly to promote apoptosis.
http://www.creativebiomart.net/

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Manufacture of vascular smooth muscle cells from the patient's skin

July 2, 2012, 7:03 pm

≫ Next: hs-cTnT predictive value of risk of death in chronic heart failure

≪ Previous: From the prokaryotic expression of macrophage-related genes ATG5

Scientists create cells constitute the vascular wall; this study may lead to new LYVE1 treatments for cardiovascular disease and better screening methods. Cambridge University scientists have for the first time with the patient's skin cells to produce different types of vascular smooth muscle cells (of SMCs, constitute the cells of the blood vessel wall).The study was partially funded by the Wellcome Trust, the findings in the June 13 published in "Nature - Biotechnology" (Nature Biotechnology).1/3 in the UK, the total number of LYZ deaths due to cardiovascular disease. Most of which is due to atherosclerosis caused by a blood vessel in the "scale" and embolism. For those patients not suitable for traditional stents or bypass treatment, an option in the future may grow new blood vessels to bypass their own blocked blood vessels.Corresponding author of the MAD2 study, the Wellcome Trust Intermediate Fellow of the University of Cambridge, Dr. Sanjay Sinha, said: "This study represents an important step, will have the ability to create the correct type of smooth muscle cells use to build new blood vessels. Other patients may benefit from these new blood vessels, including those in need of vascular grafts for dialysis patients with renal failure.In the study, scientists used embryonic MAD2L stem cells (or similar cells derived from skin samples of patients), they have the potential to form various types of body cells are called pluripotent cells (hPSCs). The use of human pluripotent stem cells (hPSCs), they found a method of manufacturing high purity vascular smooth muscle. Before employing more than capable cells (hPSCs) to produce blood cells and myocardial cells, this study is the 1BP first time in a system developed out of the main types of vascular smooth muscle cells, and this system can easily scale for clinical level of production.

Vascular smooth muscle cells derived from different tissues in the early embryo, scientists have been able to reproduce the three different types of embryonic tissue in a dish. Interestingly, these smooth muscle cells (SMCs), the response of the material (such as growth factors) can lead to vascular Madcam1 disease vary, depending on which they are the source of embryonic way. They concluded that the embryonic origin of the differences may determine some of the common vascular diseases (such as aortic aneurysm or atherosclerosis, etc.) played a part in when and where to form. Sinha added: "Using this system, we can begin to understand the origin of the smooth muscle cells (SMCs) is how to affect the development of vascular disease and why the blood vessels in some areas to be protected against the disease affects.""In addition, there are many patients suffering from a hereditary disease (such as Marfan syndrome), it affects the vascular smooth muscle cells and lead to premature cell death and disability. Through this study, the use of manufacturing by the patient skin samples pluripotent stem cells (hPSCs), we will be able to in a lab dish to create a disease carry a genetic abnormality smooth muscle cells. such 'plates' model will allow us to better understand the disease and allows us to filter some new method of treatment. "

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hs-cTnT predictive value of risk of death in chronic heart failure

July 3, 2012, 7:12 pm

≫ Next: Scientists have discovered a new mechanism of lipid metabolism regulation

≪ Previous: Manufacture of vascular smooth muscle cells from the patient's skin

Recently, Marta de Antonio from Barcelona, Spain, the researchers published in American Heart Journal, the study said, for patients with NQO2 chronic heart failure in real life, hs-cTnT can provide important predictive information for their future risk of death occurred.Heart failure remains high mortality rate. People are biological markers that reflect the different pathophysiological NR1H2 pathways to be evaluated in order to better stratify the risk of death. The purpose of this study was to assess of hs-cTnT, NT-proBNP in combination in real life, out-patient heart failure patient cohort mortality risk stratification in value.Researchers from the heart failure unit treated 876 patients (median age: 70.3 years, median left ventricular NR1H3 ejection fraction (LVEF): 34%). In addition to the risk of death has been determined predictors (age, gender, LVEF, New York Heart Association functional classification, diabetes mellitus, the estimation of glomerular filtration rate, the cause of ischemia, sodium intake, hemoglobin, receive β-blockers treatment, receiving ACEI or ARB therapy), the researchers further joint application to reflect the indicators of myocardial injury and myocardial NR1H4 contractility-hs-cTnT and NT-proBNP-to assess the risk of death in patients with heart failure. Median follow-up of 41.4 months, a total of 311 patients died. Multivariate Cox proportional hazards model analysis showed that hs-cTnT and NT-proBNP are independent predictors of mortality (p = 0.003; p = 0.003). Two at the same time increased (more than normal cut-off point value) significantly increased the death risk (HR HR 7.42; [95% CI, 5.23-10.54]; P <.001). Has established a predictive NR1I2 model of mortality risk factors were hs-cTnT and NT-proBNP into the contain, the predictive value of the model significantly improved. Comprehensive identification, correction and re-classification analysis, hs-cTnT in predicting heart failure death is better than NT-proBNP (net re-classified index of 7.7% and 1.5% respectively).

The researchers believe that patients with chronic heart failure in real life, hs-cTnT provide important predictive information to their future risk of death occurred. Hs-cTnT and NT-proBNP into the established mortality risk factors in the prediction model can better stratify the risk of death in patients with heart failure.

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Scientists have discovered a new mechanism of lipid metabolism regulation

July 4, 2012, 8:25 pm

≫ Next: constructing engineered microorganism

≪ Previous: hs-cTnT predictive value of risk of death in chronic heart failure

Recently, the internationally renowned Journal of Cell Science published the latest MCFD2 research results of researchers from the Institute of Genetics and Developmental Biology, Max-Planck of Biophysics, Institute of Chemistry, "Opposite and kept in redundant roles of the two of Drosophila Perilipins in lipid mobilization, "the article, the article, the researchers found only two Drosophila PAT family proteins Plin1 and Plin2 lipolysis both same and opposite regulation function, revealing the MCL-1 Drosophila PAT family proteins in lipid complex functions in the solution, provided a strong theoretical basis for the subsequent parsing of the PAT family proteins function in the evolutionary.Corresponding author of the article is of Genetics and Developmental Biology, Huang Hoon researcher Huang Hsun Laboratory doctoral Bi Junfeng and extension of co-first author of the paper. The Mcpt1 study was completed, and the cooperation of the Max Planck Institute for Biophysical Chemistry, Germany Ronald P. Kühnlein Laboratory, funded by the Chinese Academy of Sciences, Ministry of Science and Technology and the National Natural Science Fund Committee of.Lipids is an important form of energy storage in vivo lipid metabolism balance is very important to keep the Mdga2 human body. Lipid metabolism disorders can cause high blood lipids, insulin resistance, diabetes and fatty liver and other diseases. Cells, lipids are mainly the form of neutral lipids such as triglycerides and cholesterol ester storage is lipid droplets (lipid droplets).

PAT family proteins are highly conserved and specific localization in the lipid droplet MDH1 surface protein. Previous work found that the PAT family proteins are involved in the regulation of lipolysis. However, in vivo PAT family proteins among members of the division of labor coordination of lipid solution is still not clear.In this article, the researchers Drosophila model organisms and found that only two Drosophila PAT family protein Plin1 and Plin2 lipolysis both the same and opposite regulatory functions. Mutant and overexpression strains the fat cell phenotype analysis found that the Plin1 promote lipolysis, while Plin2 inhibition of lipolysis the Plin1 and Plin2.Further studies showed that, the Plin1 lipase HSL from the cytoplasmic localization to the surface of lipid droplets is a must. Fat cells of the Plin1 and Plin2 pairs of mutants, the lipid droplet size and lipid content was significantly lower than Plin1 and Plin2 the single mutants, the instructions Plin1 inhibit lipolysis function. The study also found that Plin1 unique C-terminal domain determines its different functions between Plin2.This study reveals the complex functions of the Drosophila PAT family proteins in lipolysis for the follow-up parsing the PAT family proteins function in the evolution to provide a strong theoretical basis.Hsun Huang researcher graduated from Xiamen University, researcher at the Institute of Genetics and Developmental Biology, Institute since 2006, selected the Hundred, the main research direction is the genetic control of animal development and disease.Last year, his lab has published articles in the PLoS Genetics journal, reveals a new mechanism for the accumulation of lipids ectopic. The new study found that the control genes, ectopic accumulation of lipid droplets and to elucidate the molecular mechanism laid the foundation for subsequent large-scale mining.

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constructing engineered microorganism

July 7, 2012, 9:39 am

≫ Next: Biotech/Microbio Student’s Project/Training Program

≪ Previous: Scientists have discovered a new mechanism of lipid metabolism regulation

Dear can anyone extend their expertise to help me out in constructing engineered microoroganism for biodegradation of pesticides.

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Biotech/Microbio Student’s Project/Training Program

July 19, 2012, 4:47 am

≫ Next: Pcr Assay Confirmation

≪ Previous: constructing engineered microorganism

Join Biotech/Microbio Student’s Project/Training Program (Early Morning & Evening batches) from July 2012 at CIBTech Jaipur

Centre for Info Bio Technology (CIBTech), Jaipur, a scientific research, publication and promotion based organization (since 2009) is conducting innovative projects, training programs (1 to 6 months duration), in the field of Biotechnology, Microbiology and Bioinformatics, for UG and PG Students from July 2012.
Timings: Early Morning and Evening Batches
Place: Near Nirman Nagar, Jaipur, Rajasthan
Email id: cibtech@yahoo.com
Mobile: 9636711774 (Dr. R.S. Negi)
Visit the link below for more details on the project areas, fee and other information
http://cibtech.org/Project-Training.htm
Please feel free to contact for any query.
Thanks

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Pcr Assay Confirmation

July 19, 2012, 9:23 pm

≫ Next: Sitagliptin can reduce reactive hypoglycemia

≪ Previous: Biotech/Microbio Student’s Project/Training Program

How PCR is helpful in detecting Plague?

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Sitagliptin can reduce reactive hypoglycemia

July 20, 2012, 1:45 am

≫ Next: U.S.scientists have found that gastric emptying rate is a key to obesity prevention

≪ Previous: Pcr Assay Confirmation

In Houston at the 94th Endocrine Society Annual Meeting proposed a NUP62 preliminary study found the diabetes drug sitagliptin can reduce postprandial hypoglycemia,which is a low-postprandial blood glucose.Mexico City's National Institute for Medical Science and Nutrition Research Institute chief researcher Dr.Francisco Gomez-Perez said that further research is needed to determine whether you can use of NusA sitagliptin as new ways of treatment of low blood sugar reactions,there is no drug that can be used treating this condition.Low blood sugar reaction called postprandial hypoglycemia,whether or not diabetes are likely to occur after eating carbohydrates(sugars).Symptoms include NUTF2 anxiety,palpitations,trembling,sweating,dizziness,tingling fingers,inability to concentrate and weakness.Gomez-Perez said that the current treatment methods include smaller meals and avoid high-sugar food intake,but these methods are not always effective.He speculated that the cause of reactive hypoglycemia are:delay the secretion of NXT1 insulin after the intake of carbohydrates.Blood sugar after a meal will usually rise,the need for insulin in a timely manner secretion(blood sugar returned to normal levels).

Doctors for adults with type 2 diabetes,sitagliptin(trade name Jienuo Wei)to lower blood sugar.Gomez-Perez and his companions speculated that the drug can reduce the symptoms of low blood sugar reaction.28 patients suffering from OAS1 reactive hypoglycemia(24 women and 4 men)100 mg once daily doses of sitagliptin tablets,or taking an appearance the same,but the role of the placebo,the researchers of these two The effect of the treatment comparison.Of placebo and sitagliptin,as well as the funding of research material obtained from Merck.Before and after two weeks of treatment,experimental participants in the dietary tolerance test to measure insulin and glucose levels.Experimental blood samples immediately before and after feeding 440-calorie meals,these meals,including 100 grams of carbohydrates and foods that can cause reactive hypoglycemia in these patients.Test the first 30 minutes of the early stages,from one hour to five hours late stage of the trial.Before the test,measured similar to insulin and blood sugar level.However,abstracts mentioned in the trials conducted in the late tolerance test taking sitagliptin group,higher blood sugar levels,and alleviate the symptoms of hypoglycemia.Sitagliptin treatment group symptom intensity is much lower than in the placebo group.0 to 10 points on the intensity of symptoms were assessed,where 0 means non-existent symptoms,10 indicates the presence of the strongest symptoms.Sitagliptin treatment group and the score of comfort units 2 and 5,respectively."Our results show that the reduction of low blood sugar and meal tolerance test early phase of insulin secretion is increased."Gomez-Perez said that,despite this result"sitagliptin seems can restore normal dynamic insulin secretion."referred to as"promising",but he also said that the recommended sitagliptin for further research is needed before the treatment of low blood sugar reaction.
http://www.creativebiomart.net/

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U.S.scientists have found that gastric emptying rate is a key to obesity prevention

July 24, 2012, 7:57 am

≫ Next: Relevant to law

≪ Previous: Sitagliptin can reduce reactive hypoglycemia

The researchers found that gastric emptying rate of the OSTN hormone how to slow down the digestive tract to suppress hunger and eating.The animal experimental results have been held in Houston,the 94th of endocrine school year was released.Guan Xinfu(Public Health,Dr.,Houston,Baylor College of Medicine assistant professor),chief researcher,said:"OTOR gastrointestinal hormones such as glucagon like peptide 2(or called GLP-2),the function is through its brain body as a neurotransmitter and fine-tune the gastric emptying."The researchers found that this activity occurs in the GLP-2 receptor,especially located in the brain nerve cells,these cells,known as POMC neurons(or the call of POMC).These neurons in the hypothalamus,the OTUB1 hypothalamus is responsible for manufacturing the part of the appetite-regulating neuropeptides in the brain.Their depth at the molecular level,and compared to the normal wild mouse POMC neurons lack of GLP-2 receptor mice showed delayed OTUB2 obesity and a higher food intake.A non-invasive breath test after consumption of liquid diet,mutant or GLP-2 receptor knockout mice also showed faster gastric emptying.Scientists know that the faster gastric emptying and food intake more.

Guan,therefore,speculated that obese people may be a problem in the OXSR1 hormones(GLP-2)receptors.GLP-2 regulation of their gastric emptying rate.Many studies have found that gastric emptying rate of non-diabetic obese people too fast.According to Guan's statement,the researchers also found that the receptor(GLP-2 receptor)to accelerate quickly(-3)in POMC neurons phosphatidylinositol kinase(PI3K)intracellular signaling pathways.This then induced neuronal excitability(signal transmission)and gene expression.Guan said that the findings in the central nervous system controls the intake of food and gastric emptying in GLP-2 plays an important role."The study has advanced our understanding of the neural circuits of the brain-gut eating behavior indirectly by regulating the gastric emptying rate adjustment,to control our weight."

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Relevant to law

July 28, 2012, 3:30 am

≫ Next: Progress of biotechnology

≪ Previous: U.S.scientists have found that gastric emptying rate is a key to obesity prevention

Your biotechnology online community can also be relevant to rules. It may play an important role for the health of person. Regulation require a minor aspect from the biotechnology online community talk. That works to the survival from the men and women.

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Progress of biotechnology

July 28, 2012, 3:43 am

≫ Next: Mutagen.

≪ Previous: Relevant to law

The biotechnology advancement is actually created ordinarilly. It might enjoy an essential position for the health of people. It might enjoy an essential position inside success of wellbeing area. The idea operates to the wellbeing on the individuals.

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Mutagen.

August 8, 2012, 10:58 pm

≫ Next: dropping iit,, help me

≪ Previous: Progress of biotechnology

What mutagen to use to make a new phenotype of plant?

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dropping iit,, help me

August 13, 2012, 11:40 pm

≫ Next: Companies should make safety trainings sessions compulsory. Want to know why?

≪ Previous: Mutagen.

hi all,,
im aakansha nd i need a help from u guys,,
i have completed my msc biotech from a reputed college and currently im persuing M Tech in biotech from iit kanpur. its getting harder and harder every passing day to live without my family. my family is in bangalore. its been only 20 days and im miserable. im thinking of leaving iit and going back to bangalore.
i want to continue my studies furthur in bangalore.

what are my options if i drop m tech in iit??
am i doing it right??
do i have any better options which would not ruin my career.
what are my options? i dont know much about it. i've heard that addmissions are available for phd in december also.

please suggest me anything u have..

thank u a lot,

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Companies should make safety trainings sessions compulsory. Want to know why?

August 24, 2012, 3:16 am

≫ Next: Use of spermidine in plant tissue culture

≪ Previous: dropping iit,, help me

Rapid globalization has brought along with it a lot of industry changes which are actually giving a visible boost to the global economy, helping it grow ‘fitter and fatter’ daily. There has been a considerable increase in the number of warehouses, factories, and high-end construction businesses, with umpteen, workers, contractors, and developers working in them. Hence the safety of all these employees should be the prime responsibility of the companies and businesses out there. This can be done by providing them with on-time safety training sessions. Companies and business can make tie-ups with safety training course providers, and start providing workplace safety training courses like fire fighting courses, to help the employees get a clear idea about workplace safety measures to be adopted. They will also be trained to handle unexpected accidents at workplace. Such courses will also educate them to avoid fatal and non-fatal injuries at workplace.
Workplace accidents may often result in a huge money loss. As you all know, insurance premiums are skyrocketing, and hence it’s always better to try our best and avoid workplace mishaps. Having proper safety training will give clear idea about workplace safety, to help workers decrease the possibility of potential incidents.
Workplace health and safety training can be made cost-effective too. Companies and businesses can send a group of employees to receive safety training from an accredited safety training provider, get them certified, and have them provide safety training programs for other employees.

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Use of spermidine in plant tissue culture

August 31, 2012, 7:19 am

≫ Next: Investments in xenotransplantation (or lack thereof)

≪ Previous: Companies should make safety trainings sessions compulsory. Want to know why?

Hey everyone,

I have a question about a polyamine called spermidine. Does anyone knows how many days/weeks/months spermidine is stable in a plant tissue culture that is in a light enviorment with a temperature of 23 degrees Celsius?

Kind Regards,

Blackmoa

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Investments in xenotransplantation (or lack thereof)

September 4, 2012, 4:35 pm

≫ Next: New Members - Introduce Yourself Here

≪ Previous: Use of spermidine in plant tissue culture

I have a rather broad question you may or may not be able to answer, but any thoughts help. I have been following developments in xenotransplantation and stem cell research focused on producing fully functional replacement islet cells. I personally think the xeno path seems the most promising (near-term) for developing treatments for type 1 diabetes, specifically those biotechs working on encapsulation technology for porcine islets and not genetic modification or engineering. However, I cannot help but notice that xenotransplantation is attracting very little media attention and, more crucially, little to no investment from big pharmaceutical companies in comparison to the stem cell enterprise. I realize there are concerns over immune response and the porcine endogenous retrovirus, but there are several companies getting past these obstacles in very promising ways i.e. through encapsulation and the discovery of pigs that don't carry PERV. Why is xeno not catching on in big pharma? Why does the general public, biotech, and pharma industry seem to care so much more about stem cell science that lacks the near-term results of xeno - especially for insulin dependent diabetes? This might just be my impression, if so could you point me in the direction of where I can find more information about venture capital investments in xeno.

Thanks!

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