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Biotechnology Forums - https://www.biotechnologyforums.com
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    HAI ALL GUIDERS(sir or mam),I am a biotechnology final year student .please help me in choosing project .iam so interest in pharma.
    and please give me solution,how the enzyme is isolated from fruits  or vegtables

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    Summary: Ongoing exploration has uncovered that develop cells can be reinvented into re-deployable foundational microorganisms without coordinate hereditary alteration – by binding them to a characterized geometric space for a broadened timeframe.

    Immature microorganisms are the clean slate on which every specific cell in our bodies are manufactured and they are the establishment for each organ and tissue in the body.
    Ongoing exploration drove by Professor G.V. Shivashankar of the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) and the FIRC Institute of Molecular Oncology (IFOM) in Italy, has uncovered that develop cells can be reconstructed into re-deployable immature microorganisms without coordinate hereditary alteration – by limiting them to a characterized geometric space for an expanded timeframe.

    “Our achievement discoveries will introduce another age of undifferentiated organism innovations for tissue designing and regenerative solution that may beat the negative impacts of genomic control,” said Prof Shivashankar.

    Turning back the cellular clock

    It has been over 10 years since researchers initially demonstrated that developing cells can be reconstructed in the lab to wind up pluripotent undeveloped cells that are fit for being created into any cell compose in the body. In those early examinations, specialists hereditarily adjusted develop cells by presenting outer elements that reset the genomic projects of the cells, basically making things the same as before and returning them to an undifferentiated or unspecialized state. The resultant lab-made cells, known as prompted pluripotent undifferentiated cells (iPSCs) would then be able to be customized into various cell composes for use in tissue repair, medicate disclosure and even to develop new organs for transplant. Critically, these phones should not be collected from incipient organisms.

    Be that as it may, a noteworthy impediment is a propensity for any specific cell that is produced from iPSCs, to shape tumors subsequent to being brought into the body. To comprehend why this happened, analysts turned their concentration to seeing how foundational microorganism separation and development is controlled in the body, and specifically, how cells normally return to a juvenile immature microorganism like state or change over to another phone write, amid improvement, or in tissue support.

    Prof Shivashankar’s group of scientists has demonstrated that develop cells can be reinvented, in vitro, into pluripotent foundational microorganisms without hereditarily altering the developing cells, just by binding the phones to a characterized region for development.

    Resetting mature cells

    At the point when fibroblast cells (a kind of develop cell found in connective tissue, for example, ligaments and tendons) were kept to rectangular zones, they immediately accepted the state of the substrate (the surface or medium that the cells are appended to). In light of past work from the Shivashankar lab, this showed the phones were estimating and reacting to the physical properties of their condition, and passing on this data to the core where DNA bundling and genome projects would adjust in like manner.

    The group developed the cells more than 10 days until the point that they shaped circular bunches of cells. Hereditary examination of the cells inside these groups uncovered that particular attributes of chromatin (the consolidated type of bundled DNA) typically connected with developing fibroblasts were lost by the 6th day. By the tenth day, the cells communicated qualities regularly connected with embryonic immature microorganisms and iPSCs. The specialists have now discovered that by binding the develop cells for an expanded timeframe, develop fibroblasts can be transformed into pluripotent undifferentiated organisms.

    To affirm that the fibroblasts had without a doubt been reconstructed into undeveloped cells, the analysts at that point coordinated their development, with high effectiveness, into two diverse specific cell writes. A few cells were additionally coordinated once more into fibroblasts.

    Stem cell technologies redefined

    The physical parameters utilized as a part of the investigation are intelligent of the transient geometric imperatives that cells can be presented to in the body. For instance, amid improvement, the foundation of geometric examples and specialties are fundamental in the development of utilitarian tissues and organs. Essentially, when tissue is harmed, either through damage or malady, cells will encounter sudden adjustments to their condition. For each situation, develop cells may return to a pluripotent, undeveloped cell-like state, before being redeployed as particular cells for the repair or support of the tissue.

    “While it is settled that restricting foundational microorganisms to characterized geometric examples and substrate properties can coordinate their separation into particular cells, this investigation appears out of the blue that mechanical prompts can reset the genomic projects of developing cells and return them to a pluripotent state,” Prof Shivashankar clarified.
    He included, “The utilization of geometric requirements to reprogramme develop cells may better mirror the procedure happening normally inside the body. All the more vitally, our discoveries enable analysts to produce undifferentiated organisms from developing cells with high productivity and without hereditarily adjusting them.”

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  • 07/16/18--10:12: Hello
  • Hii.. Everyone i have joined in bit for the course b.Tech biotechnology. I need your help regarding the reference books to be preferred for studying.

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    Msc biotechnology, microbiology or biochemistry? Or should I go for msc in pharmaceutical chemistry and forensic sciences???

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  • 07/20/18--02:17: Biostats
  • I'm currently doing btech biotech 2nd year. What do I have to do if i have to take up Masters biostats abroad

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    Need biotech jobs

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  • 07/21/18--07:32: Suggestions
  • Hello. I have recently completed my MSc in biotechnology . And now i am interested in working in food industry or maybe any applied biotechnology industry. So can anyone suggest me what should i do now?

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  • 07/26/18--21:16: Internship
  • Is there any internship available for bsc completed students in the biotechnology field, before doing an msc ?

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  • 07/27/18--11:32: Job
  • What are the major benefits of doing pg in food tech after completing bsc in biotechnology?

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  • 07/30/18--09:18: Dissertation Related query
  • I am pursuing M.Sc in Biotechnology. What project should I choose for my M.Sc dissertation? Specially i m interested for Bioinformatics. So please suggest me some bioinformatics related topics for my dissertation. Thank u

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  • 07/30/18--21:00: Genetic engineering course
  • Any one is there to help me in this genetic engineering field for the study material material and syllabuses .

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  • 08/01/18--09:09: Summer internships
  • Hi, i am a b.tech biotech student. Can anyone say some companies and their details for internships known to u in the surroudings of chennai and bangalore..??

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  • 08/07/18--01:26: I need help
  • want to know about IHC Protocol? Guide me.

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    Fresher jobs

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    Events: SIG Workshop to discuss developments in computational pathology and its interfacing opportunities with bioinformatics during ECCB 2018

    Sunday, September 9, 2018
    Athens, Greece (during ECCB2018)
    cpw2018.org

    Submission deadline for abstracts has been extended until August 15. Travel awards available!

    Digital and computational pathology are increasingly used to study biological processes and diseases as novel molecular probing and imaging techniques allow the measurement of single molecules in whole tissue sections. Resulting multi-gigapixel images can be viewed on a computer screen via dedicated software. However, automated analysis of such large-scale datasets is challenging and their combination with omics data is not trivial. This workshop wants to facilitate bridging opportunities between the bioinformatics and tissue image analysis communities.

    This second edition is organized as a full-day workshop during ECCB 2018 (www.eccb18.org).
    SCOPE
    Computational pathology exists at the interphase between bioinformatics, machine learning, and digital pathology (microscopy). Submissions from all topics of interest are welcome (non-exhaustive list):

    Machine learning and image analysis for quantification in digital pathology (in 2D & 3D), Novel approaches (e.g. spatial or graph-based methods) to extract high-level features (e.g. molecular networks or spatial expression patterns) from tissue images for systems pathology, Software development methodologies and tools to ease the exploitation of large tissue images and integration with omics data, Novel molecular imaging techniques on tissues (molecular pathology, next generation pathology) and their analysis challenges, e.g. in situ hybridization, mass spectrometry imaging of formalin-fixed paraffin-embedded tissues, mass cytometry, and other spectroscopy techniques (Raman, ...), ... Research applications on non-human model organisms
    KEYNOTE SPEAKERS
    The following keynote speakers are confirmed to speak at the conference:

    Thomas Fuchs, Memorial Sloan Kettering Cancer Center
    Chakra Chennubhotla, University of Pittsburgh
    Derek Magee, University of Leeds
    SUBMISSIONS
    The conference solicits oral talks, posters, and proceeding papers contributions of original work or work that was recently accepted or published in a peer-reviewed journal or at a high level international conference. In the latter case, the publication reference should be clearly mentioned, and the abstracts should be checked mainly for relevance, rather than receive a full review.

    Conference proceedings will be published by the Journal of Pathology Informatics.

    The program committee will decide which contributions are selected for an oral presentation, and which ones are presented during a poster session. For submission instructions, please refer to www.fourwav.es/cpw2018
    KEY DATES
    Submission deadline: August 15, 2018.
    Conference: Sunday September 9, 2018.

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    I want to do my career in Regenerative medicine, abroad (primarily US or Germany/ Netherlands)

    I am presently pursuing Medical Biotechnology from DY Patil University, Pune in my final year.

    I wish to have a better chance of good job overseas and for that, I do wish to do my masters there itself (abroad).

    Now my query, as a need of my curriculum, I am supposed to do a 6-month internship during my final semester (i.e from Jan 2019 to June 2019) - I want to use this opportunity of Internship for getting me the best possible career in Regenerative Medicine field.

    Hence, want suggestions of all the stalwarts as well as members here, on which place (private lab or university) must I do my Internship - I am also ready to go abroad for this internship, to boost my career - and also wish that this internship should help in landing me into the best possible University for Regenerative medicine.

    I hope i am able to pen down my query well.  Your response is highly appreciated.

    Many thanks to all of you here well in advance. Smile

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  • 08/13/18--10:23: Books
  • Can anyone send me the soft copy of "Bioinformatics- Methods and Applications: Genomics, Proteomics and Drug Discovery"(4th edition) by S.C. Rastogi, P. Rastogi, N. Mendiratta

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  • 08/13/18--12:41: Need a job
  • Hi Sir/Ma'am,

    I am fresher, I have completed my B. Sc +M.Sc in biotechnology in may 2018 only. I am not preparing for CSIR right now. I need a job related to my field only as my core interest is in R&D only. I have good internship records. Please suggest me some jobs suitable to my profile. I am very interested in Forensic DNA Analyst profile
    .
    With Regards.

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  • 08/19/18--07:41: Gate biotech preparation
  • I want to go for an offline coaching in pune for gate.Are there any please ppl let me know fast ?

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  • 08/19/18--08:16: Biotechnology
  • What is the scope and best institutes for pursuing msc in biotechnology if a student has PCB in class 12?